Endocrine Abstracts

Introduction: Multiple endocrine neoplasia type 2A syndrome (MEN 2A) is caused by a germline mutation in the RET proto-oncogene and its phenotype includes medullary thyroid cancer, pheochromocytoma and primary hyperparathyroidism (PHPT). Parathyroid reimplantation in the sternocleidomastoid muscle or in the brachioradial muscle can be performed in case of intraoperative lesion of the parathyroid glands. In some cases, PHPT may occur due to the proliferation of autotransplanted...

Introduction: Differentiated thyroid carcinoma is usually associated with a good prognosis. However, some of these tumors (5%) are radioiodine refractory and have different progression, associated with poor prognosis. In these situations, some tyrosine kinase inhibitors (TKI) can be used. We present a clinical case showing the difficulties in the follow-up and treatment of these patients.Clinical case: A 60 years old woman, with a “multicentric papi...

IntroductionThe development of Diabetes mellitus type 1 (DMT1) is considered as an autoimmune pro-inflammatory process. Human enteroviruses are thought to be also a cause. These viruses influence beta cells and cause expression of immunological factors. The affected cells destroy the related beta cells. The aim of the work is to study the genetic polymorphisms in IP-10/CXCL10 and its receptors CXCR3 and TLR4 in order to predict expression of DMT1.<p ...

IntroductionHypoparathyroidism still remains the only hormone-deficiency related disorder whose standard treatment is not based on replacing the missing hormone. In the last few years, there has been growing evidence on the use of recombinant human PTH, mostly with subcutaneous injections of rhPTH(1–34). More recently, some clinicians have tried to administer teriparatide through a continuous delivery system using insulin pumps.<p class="abstext...

IntroductionThe Carney Complex (CNC) is a rare, autosomal dominant, multiple endocrine neoplasia. It involves multiple endocrine glands, cardiac and skin myxomas, mammary fibroadenomas and mucocutaneous pigmentation. Cushing’s syndrome, due to primary pigmented nodular adrenocortical disease (PPNAD), is described in 25% of the cases.Case reportWoman, 21-year-old, was refered for secondary amenorrhea. Med...

IntroductionThe measurement of serum thyroglobulin (Tg), a glycoprotein produced exclusively by follicular thyroid cells, is an important tumour marker used in the follow-up of patients with differentiated thyroid carcinoma (DTC) and residual or recurrent disease. However, its role as a screening tool before thyroid surgery is not yet defined, as benign conditions can result in its increase.ObjectiveThe aim o...

Background: Adrenal insufficiency (AI) is a rare condition affecting children, potentially life-threatening. Autoimmune adrenalitis accounts for 15% of all cases of primary adrenal insufficiency in pediatric age. Most symptoms are usually unspecific, making the diagnosis quite challenging.Objective: The aim of the study was to describe clinical presentation, biochemical abnormalities, treatment and the clinical course of patients with autoimmune AI.<...

Introduction: Thyroglossal duct cysts (TDC) are a very frequent congenital neck mass and are mostly benign. Papillary thyroid carcinoma (PTC) originating from a TDC represents an infrequent finding. Usually, the diagnosis is only made postoperatively after cyst’s excision.Case report: A 38-years old female patient was referred to the Endocrinology department due to Graves’ disease. She had been treated with antithyroid drugs for 18 months witho...

Introduction: Adrenal hematomas are a relatively rare clinical condition and its prevalence has been reported to be about 1%. Although various causes have been proposed, the ethology and pathophysiology are still not fully understood, and the symptoms range is very variable, from asymptomatic situations to haemorrhagic shock. Imaging is a challenging method to establish the diagnosis of adrenal hematomas, and in most cases, it is only possible after surgery. Surgery is routine...

Objective: One of the hallmarks of cancer is its unlimited replicative potential. Recently, telomerase promoter (TERTp) mutations were presented as novel mechanism for telomerase re-activation/expression. Due to this fact, it was our objective to study pancreatic endocrine tumours (PET) and related cell lines, to determine if TERTp mutations were present.Design: We performed characterization of the TERTp in a series of 55 PETs and three common PET cell l...